Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells

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Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells.

Clusterin (apolipoprotein J) is an extracellular glycoprotein that might exert functions in development, cell death and lipid transport. Clusterin gene expression is elevated at sites of tissue remodelling, such as differentiation and apoptosis; however, the signals responsible for this regulation have not been identified. We use here the clusterin gene as a model system to examine expression i...

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Ionic Responses and Growth Stimulation Induced Nerve Growth Factor and Epidermal Growth Factor in Rat Pheochromocytoma (PC12) Cells

Rat pheochromocytoma cells (clone PC12) respond to nerve growth factor (NGF) by the acquirement of a phenotype resembling neuronal cells. In an earlier study we showed that NGF causes an increase in Na+,K + pump activity, as monitored by ouabain-sensitive Rb + influx. Here we show that addition of epidermal growth factor (EGF) to PC12 cells resulted in a stimulation of Na+,K ÷ pump activity as ...

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Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cells

Rat pheochromocytoma cells (clone PC12) respond to nerve growth factor (NGF) by the acquirement of a phenotype resembling neuronal cells. In an earlier study we showed that NGF causes an increase in Na+,K+ pump activity, as monitored by ouabain-sensitive Rb+ influx. Here we show that addition of epidermal growth factor (EGF) to PC12 cells resulted in a stimulation of Na+,K+ pump activity as wel...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1999

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj3390759